The invention refers to a method for production of 1(10).beta.-epoxy-13-dimethylamino-5,7a,6, 11.beta.(H)-guaia-3(4)-en-6,12-olide hydrochloride, the lyophilized, antitumor preparation having radio-sensitizing and immunomodulating activities, including extraction of the natural raw material endemic plant Artemisia glabella Kar. et Kir., separation obtained resin on individual components with receiving technical arglabin from which dimethylaminoarglabin hydrochloride is synthesized, with its subsequent purification, drying and lyophilization. In this method the extraction is carried out with use of fluid carbon dioxide as extragent at pressure 150.+-.2-10.sup.5 Pa and temperature 60.degree. C. i 0.5, the separation resin on individual components is carried out by method of preparative fluid chromatography with application of reversed phase C.sub.18, at the synthesis of dimethylaminoarglabin hydrochloride technical arglabin is solved in acetonitrile at the weight ratio 1:10 with addition dimethylammonium dimethylcarbamat in the molar ratio 1:1.62.

 
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