Systems and methods are disclosed for forming reconfigurable neural networks with interconnected FPGAs each having a packet router. Neural network nodes are formed within the FPGAs and connections between nodes within an FPGA and connections to nodes external to the FPGA are made using packet routers that are configured within each FPGA. The FPGAs can be connected to each other using high-speed interconnects, such as high-speed serial digital interconnects. The FPGA arrays with packet routing allow for dynamic and reconfigurable neural networks to be formed thereby greatly improving the performance and intelligence of the neural network.