A frame or subframe for a tractor-trailer for supporting one or more axle/suspension systems includes a pair of spaced-apart, parallel, elongated, and longitudinally extending main members. At least one cross member structure extends between and is connected to the longitudinal main members using structural nodes. A bonding adhesive, or other suitable means of attachment, connects the cross member structure and the structural nodes to one another and to the main members. The structural nodes distribute loads encountered during vehicle operation generally over a relatively large area thereby generally reducing the concentration of such loadings at the connections, and assist in generally evenly distributing loads between the cross member structure and the main members to effectively react lateral, longitudinal, vertical, and racking loads. The combination of greater load distribution and reduced loading concentrations allows the structure to be constructed from lighter weight materials.