A personnel security screening and control system includes a screening center having a threat screening system incorporating a sample collector and a sample analyzer. The sample collector obtains a threat sample from the subject which is subsequently analyzed by the sample analyzer to determine whether the individual represents a potential threat. The overall system also incorporates a demographic screening system including a demographic collector and a demographic analyzer. The demographic collector obtains a demographic indicator which is subsequently analyzed to determine a particular demographic of the subject. The screening center provides an interactive system for determining whether a subject has encountered or handled a substance that may pose a potential threat, e.g., explosives, and also presents targeting advertising or other information to the subject.