An endoscope system and method includes an endoscope tip coupled to a endoscope console for providing images of anatomical features imaged using the endoscope system. The system also includes a calibration device having known optical properties. The calibration device is imaged using the endoscope system, and data corresponding to the image is obtained. This data are compared to data corresponding to the known optical properties of the calibration device. Based on this comparison, calibration data corresponding to imaging errors of the endoscope system are obtained. The calibration data are used to calibrate the endoscope system.