Methods for protection of a human from SVFS comprise the administration of
a flavonoid compound of the basic structures 2-phenyl-4H-1-benzopyran or
2-phenyl-4-keto-1-benzopyran or glycosides thereof, alone or, optionally,
together with one or more of an olive kernel extract, a non-bovine
sulfated proteoglycan, bitter willow extract, a D-hexosamine sulfate,
S-adenosylmethionine, folic acid, vitamin B12 and a serotonin inhibitor.
Such treatment prevents, reduces or eliminates SVFS in patients receiving
as much as 300-3000 mg/day of niacin therapeutically, whether
administered prior to, or along with, an anti-SVFS composition.