A mole analysis program generates a digital signature for a first mole, based on a digital image of first, second, and third moles. The program may then determine whether the first mole matches a previously imaged mole, based on the digital signature for the first mole and baseline data with baseline signatures for previously imaged moles. In response to determining that the first mole matches a previously imaged mole, the program may automatically determine whether the first mole has changed. In various embodiments, the digital signature may include angle entries for the digital signature and/or distance entries for the first signature. An angle entry may represent an angle between two lines to connect the first mole with the second mole and the third mole. A distance entry may correspond to the distance between the first mole and the second mole. Other embodiments are described and claimed.