The present invention relates to a method for preventing or treating edema or dermatitis using Glehnia littoralis Fr. Schmidt et Miquel extract. The Glehnia littoralis Fr. Schmidt et Miquel extract extracted using water, alcohol or a mixture thereof as a solvent inhibits production or secretion of cytokine regulators, the inflammatory mediators, but has no side effects such as toxicity, so that the extract can be effectively used for preventing and treating edema or different types of dermatitis accompanying inflammation.