An isolated human antibody or a fragment of a human antibody which specifically binds to human delta-like ligand 4 (hDII4) and blocks hDII4 binding to a Notch receptor. The human anti-hDII4 antibody or antibody fragment binds dimeric hDII4 with an affinity of 75 pM or better, as measured by surface plasmon resonance.

 
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< Methods and compositions for generating bioactive assemblies of increased complexity and uses

> antibodies binding to a C-terminal fragment of apoliopoprotein E

> Membrane scaffold proteins and embedded membrane proteins
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