A method for virtual endoscopy in a lumen includes acquiring from a patient an imaging dataset exhibiting a lesion external to a lumen wall; deriving a three-dimensional (3-D) volume of the lesion; obtaining data on maximum bend characteristics for a given endoscope; and deriving projection criteria, based on the 3-D volume and the maximum bend, for projecting an endoluminal image of said lesion, indicating an optimal biopsy insertion point.

 
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