The invention concerns a method for detecting or locating one or several
genes of one or several specific A DNA sequence or one or several
molecules reacting with DNA on a B DNA characterised in that it consists
in: (a) fixing and combing a certain amount of said B DNA on a combing
surface; (b) reacting the product of the B combing with one or several
probes, linked with the gene(s) or specific A DNA sequences, or with the
molecules capable of reacting with DNA; (c) extracting information
corresponding to at least one of the following categories: (1) the
position of the probes. (2) the distance between the probes, (3) the size
of the probes (the total sum of sizes for quantifying the number of
hybridised probes) for determining therefrom the presence, the location
and/or the amount of genes or specific A DNA sequences. This method can
be used in particular for the diagnosis of genetic diseases.