The invention provides chroman compounds having formula 1 ##STR00001## wherein R.sup.1 is (1C-4C)alkyl, (2C-4C)alkenyl or (2C-4C)alkynyl, and independently R.sup.1 has a cis-orientation in relation to the exocyclic phenyl group at the 2-position of the skeleton; R.sup.4 is H, Hal, CF.sub.3, OH or (1C-2C)alkyloxy; R.sup.2, R.sup.3, and R.sup.5are independently H, Hal, CF.sub.3, (1C-4C)alkyl, (2C-4C)alkenyl or (2C-4C)alkynyl and prodrugs thereof for the manufacture of a medicine for estrogen-receptor related treatments.

 
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