The invention relates to the field of molecular biology, virology and medicine and, more specifically, to novel derivatives of 3'-azido-3'-deoxythymidine phosphonates with the following general formula ##STR00001## where R=alkyl groups, including those containing halogen atoms, carboxy-, hydroxy-, alkoxy- and acyloxy- groups as well as substituted aminocarbonyl groups. The compounds can be used as antiviral agents as they have low toxicity and can effectively inhibit replication of type 1 immunodeficiency virus in MT-4 cell culture and generate AZT in mammalians ensuring a gradual increase of its concentration in the blood.

 
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