The invention provides tissue engineering compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The matrices comprise biodegradable polymer fibers capable of the controlled delivery of therapeutic agents. The spatial and temporal distribution of released therapeutic agents is controlled by use of defined nonhomogeneous patterns of therapeutic agents in the matrices.

 
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> Synthetic biomaterial compound of calcium phosphate phases particularly adapted for supporting bone cell activity

> Process for the production of multiple cross-linked hyaluronic acid derivatives

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