A compound of the formula (Y): where; R.sub.1 is O, S; R.sub.2 is a
nitrogen-containing heterocycle; R.sub.3 is H, C.sub.1-C.sub.3 alkyl; X
is --(CR.sub.8R.sub.8').sub.n-D-(CR.sub.8R.sub.8').sub.m--; D is a bond,
--NR.sub.9--, --O--, --S--, --S(.dbd.O)-- or --S(.dbd.O).sub.2--; n and m
are independently 0, 1 or 2, R.sub.8 and R.sub.8' are independently H,
C.sub.1-C.sub.3 alkyl, haloC.sub.1-C.sub.3alkyl, hydroxy, or R.sub.8 and
R.sub.8' together with their adjacent C atom is --C(.dbd.O)--; R.sub.9 is
independently H, C.sub.1-C.sub.3 alkyl; E is CH.sub.2--, --CHOH--,
--C(.dbd.O)--, --NR.sub.9--, --O--, --S--, --S(.dbd.O).sub.2--; n and m
are independently 0, 1 or 2; p and q are independently 0, 1 or 2, where
p+q.ltoreq.2; R.sub.10 is an optionally substituted carbocycle or
heterocycle; R.sub.11 is independently H, C.sub.1-C.sub.3 alkyl, halo
substituted C.sub.1-C.sub.3alkyl, hydroxy; have utility as HIV
antivirals.
