The problem of the present invention is to provide a useful compound as a glucokinase activating agent, which is the oxime derivative of the formula [I]: ##STR00001## wherein Ring A is aryl or heteroaryl; Q is cycloalkyl, heterocycle, alkyl or alkenyl; Ring T is heteroaryl or heterocycle; R.sup.1 and R.sup.2 are independently hydrogen atom, halogen atom, cycloalkylsulfonyl or the like; R.sup.3 and R.sup.4 are independently hydrogen atom, hydroxy, oxo, halogen atom or the like; R.sup.5 is hydrogen atom, halogen atom, cyano, nitro, tetrazolyl or the like; or a pharmaceutically acceptable salt thereof.