There are disclosed .beta.-sheet mimetics and methods relating to the same for imparting or stabilizing the .beta.-sheet structure of a peptide, protein or molecule. In one aspect, .beta.-sheet mimetics are disclosed having utility as protease inhibitors in general and, more specifically, as serine protease inhibitors such as thrombin, elastase and Factor X inhibitors. In one embodiment, the .beta.-sheet mimetic is a thrombin inhibitor.

 
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< Annexins, derivatives thereof, and annexin-cys variants, as well as therapeutic and diagnostic uses thereof

> Poly(ester amide) block copolymers

> Polymeric immunoglobulin fusion proteins that target low-affinity Fc.gamma.receptors

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