The present invention is directed to substituted 4H-chromene and analogs thereof, represented by the general Formula I: ##STR00001## wherein A, B, X, Y, Z and R.sub.5 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

 
Web www.patentalert.com

< Benzopyran derivatives, method of production and use thereof

> Amphiphilic [5:1]- and [3:3]- hexakisadducts of fullerenes

> Geranyl compounds

~ 00507