The present invention is directed to compositions and methods related to
soluble G-protein coupled receptors (sGPCR). In ceratin aspects the
invention includes compositions and methods related to a soluble
corticotropin releasing factor receptor related protein, sCRFR2, as well
as its effects on CRFR signaling and interaction between CRF family
ligand and CRFR receptors, including but not limited to CRFR2, CRFR1 and
functional or signaling capable variants thereof.