Compositions and methods for treating mammalian diseases or conditions characterized by undesirable angiogenesis by administering an effective amount of a compound of the formulae: ##STR00001## wherein R.sub.a is selected from --OCH.sub.3, --OCH.sub.2CH.sub.3 or --CCCH.sub.3; and Z is selected from >C(H)--OH, >C(H)--O-alkyl, >C(H)--O-sulfamate, where alkyl is a linear, branched and/or cyclic hydrocarbon chain comprising 1 to 10 carbons.