A pixel array with flexible circuit layout is disclosed, which comprises: a substrate, having a first surface; a plurality of scan lines; and a plurality of data lines; wherein the plural scan lines are disposed on the first surface while each has a profile defined by a non-linear first function, and the plural data lines are disposed on the first surface while each has a profile defined by a non-linear second function. When the pixel array is adapted for a flexible display and the display is being bended, the flexible circuit layout of the pixel array of the invention can effectively reduce the risk of the snapping of the conductive wires used in the pixel array so that the flexibility and reliability of the flexible display are enhanced.