Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.

 
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< Antigen-binding polypeptides and their uses

> Ion sources, systems and methods

> Polypeptides having antimicrobial activity and polynucleotides encoding same

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