The invention provides a method and system for constructing a new space or improving and existing space to achieve and maintain high air quality in the interior of the space by limiting airborne allergens, VOCs, particulates, and bio-aerosols therein. One method of the invention, includes the steps of sampling the air quality of the indoor space, removing suspected sources of pollutants, selecting replacement materials having low-VOC off gassing, testing the air quality to ensure the space meets a pre-determined base line air quality, and maintaining the air quality of the indoor space at or below the pre-determined base line air quality.