Under adaptive frequency reuse technique, mobile stations in a cellular orthogonal frequency division multiple access (OFDMA) system are served by different radio resource regions with appropriate frequency reuse patterns to mitigate inter-cell interference and improve system capacity. In a first novel aspect, the mobile stations measure interference statistics and obtain interference measurement results. The mobile stations report the obtained interference measurement results to serving base stations. The serving base stations determine adaptive frequency reuse patterns based on the received interference measurement result. In a second novel aspect, a radio resource control element receives the interference measurement results, determines frequency reuse patterns and configures radio resource allocation based on the received interference measurement results. In a third novel aspect, the base stations obtain the interference measurement results and schedule the mobile stations to be served with appropriate radio resource regions.