An anti-pinch control utilizes certain vehicle information to adjust anti-pinch parameters used to control movement of a powered closure member. The anti-pinch control determines whether a vehicle is stationary, and identifies if an engine is "on" or "off." A low pinch force parameter is applied when the vehicle is stationary and when the engine is "off." A high pinch force parameter is applied when the engine is "on." When the low pinch force parameter is being applied, other safety features could also be incorporated into the control, such as preventing release of a parking brake or preventing movement of a gear selector out of park, for example.