B-cell epitope peptides of HSP 65, particularly the peptides comprising
the amino acid sequence substantially as denoted by SEQ ID: Nos. 1-5 and
their biologically functional homologues and derivatives thereof. Also
included are polyclonal and monoclonal antibodies directed against them
and their compositions for passive immunization against inflammatory and
autoimmune diseases and in the treatment of inflammatory and autoimmune
diseases. Also encompassed are diagnostic uses of these antibodies, for
identifying people at risk of developing arthritis or diabetes, and a
method of monitoring progress of the disease conditions and disease
prognosis.