A catheter assembly and method for constructing same comprises engagement of a proximal tubular member to a distal outer tubular member. At least a portion of the exterior surface of the proximal tubular member comprises at least one thermoplastic polymer. At least a portion of the end region of the distal outer tubular member is engaged to at least a portion of the end region of the proximal tubular member to define an engagement region. The proximal tubular member and the distal outer tubular member define a continuous central lumen therethrough. At least a portion of the proximal tubular member is disposed about an inner support layer. At least a portion of the inner support layer extends distally across the engagement region and into the lumen of the distal outer tubular member.

 
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> Nucleic acids encoding B7-Like molecules and uses thereof

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