A capture system captures detectable attributes of a user. A differential system compares the detectable attributes with a normalized model of attributes, wherein the normalized model of attributes characterize normal representative attribute values across a sample of a plurality of users and generates differential attributes representing the differences between the detectable attributes and the normalized model of attributes. Multiple separate avatar creator systems receive the differential attributes and each apply the differential attributes to different base avatars to create custom avatars which reflect a selection of the detectable attributes of the user which are distinguishable from the normalized model of attributes.

 
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> Estrogen receptor intramolecular folding systems, estrogen receptor intramolecular folding sensors, methods of use thereof, methods of detecting ER ligands, and methods of detecting ER agonists and antagonists

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