Neurite outgrowth-promoting prostaglandins (NEPPs) and other electrophilic
compounds bind to Keap1, a negative regulator of the transcription factor
Nrf2, and prevent Keap1-mediated inactivation of Nrf2 and, thus, enhance
Nrf2 translocation into the nucleus of neuronal cells. Therefore,
neuroprotective compositions and related methods are provided that employ
such neuroprotective compounds, and prodrugs of such compounds, to cause
dissociation of Nrf2 from a Keap1/Nrf2 complex.