Configurable animal housing (caging) is arranged from an assortment of modules consisting of interchangeable frame cores, interstages, walls and divider panels that address a broad spectrum of animal housing needs. Various configurations include both open living and enrichment areas as well as isolation housing and are easily achieved using a quick-disconnect approach to assembly. Animal resistant lock assemblies hold modules together and use a common key to permit rapid changes of configuration without tools. Systems can address configurations for wall mounting, mobile racking, individual, and group housing, and almost any other configuration animal caregivers would want.