A cerebral interface system has a housing mechanism configured to be at least partially spaced in a cavity formed in the subject's skull; an attaching mechanism for attaching the housing mechanism to the subject's skull; a sealing mechanism for providing a fluid-tight seal between the housing mechanism and the subject's skull; a control mechanism spaced within the housing mechanism; a communication mechanism with one or more sensors embedded in the subject's brain connecting the control mechanism to the subject's brain; and a power source spaced within the housing mechanism. Preferably, an inner wall thereof is substantially aligned with the surrounding inner surface of the subject's skull and an outer wall thereof is substantially aligned with the surrounding outer surface of the subject's skull, or may include an auxiliary portion extending tangentially outwardly from the cavity formed in the subject's skull and having substantially the same profile as the subject's skull thereunder. The system may include a communication link wirelessly connecting the control mechanism to external apparatus for transmitting or receiving information related to detecting, predicting, controlling, or aborting abnormal brain activity of the subject. Alternatively, the control mechanism may be self-contained without need for such external apparatus. An output mechanism is provided that is activatable by the control mechanism. The attaching mechanism may include removable fastening means. The housing mechanism is preferably constructed of titanium. The invention also comprises a method for practicing the invention.