The invention relates to a pharmaceutical composition comprising at least one phenol derivative represented by formula (I) ##STR00001## wherein R.sup.1 represents a hydrogen atom, a halogen atom or a hydrocarbon group containing up to 12 carbon atoms; R.sup.2 represents a hydrogen atom or a C.sub.1-C.sub.7 alkyl group; wherein R.sup.1 and R.sup.2 may optionally form a carbocyclic 5- or 6-membered ring; R.sup.3 represents a hydrogen atom, a halogen atom or a C.sub.1-C.sub.7alkyl group; R.sup.4 represents a hydrogen atom, a C.sub.1-C.sub.7 alkyl group or a halogen atom; R.sup.5 represents hydrogen atom, a halogen atom or a C.sub.1-C.sub.7 alkyl group; and R.sup.6 represents a hydrogen atom, a C.sub.1-C.sub.7 alkyl group or a C.sub.2 or C.sub.3 alkenyl group, under the proviso that R.sup.2 and R.sup.4 can only both represent a hydrogen atom if both R.sup.1 and R.sup.5 represent a C.sub.1-C.sub.7 alkyl group and R.sup.3 represents a halogen atom. The composition is particularly useful for the blockage of sodium channels and/or influencing the kinetics of sodium channels and thus can be used as local anesthetic, antidysrhythmic, anticonvulsant/antiepilepticand spasmolytic.