Peptides having bradykinin-antagonistic action are suitable for the
production of pharmaceuticals for the prophylaxis and therapy of diseases
in whose course an increased activity of matrix metalloproteinases is
involved. These include diseases such as degenerative joint diseases, for
example osteoarthrosis, spondylosis and chondroporosis after joint trauma
or relatively long immobilization of a joint after meniscus or patella
injuries or torn ligaments. The invention therefore relates to the use of
a compound of the formula I,
A-B-X-E-F-K-(D)-TIC-G-M-F'-I (I)
for the production of pharmaceuticals for the treatment of degenerative
joint diseases, wherein A, B, X, E, F, K, (D)-TIC, G, M, F' and I are as
defined herein.