A seed point is selected inside a structure that is to be segmented in image data. An adaptive model is defined around the seed point, and a preprocessing filter is applied only within the bounding region. A presegmentation of the preprocessed result is performed, and the bounding region is expanded if necessary to accommodate the presegmentation result. An adaptive model for post-processing may be used. The model is translated, rotated and scaled to find a best fit with the pre-segmented data. Additional models can be grown based on testing performed on points on a perimeter of previous models to improve the segmentation of an object.