Methods and systems for treatment of coronary artery disease (CAD) include
implantation of the discharge portion(s) of a catheter and, optionally,
electrodes on a lead, near the tissue(s) to be stimulated. Stimulation
pulses, i.e., drug infusion pulses and optional electrical pulses, are
supplied by a stimulator implanted remotely, and through the catheter or
lead, which is tunneled subcutaneously between the stimulator and
stimulation site. Stimulation sites include the coronary arteries, the
aorta, the left ventricle, the left atrium, and/or the pulmonary veins,
among other locations. Disclosed treatments include drugs used for acute
treatment of CAD, for chronic treatment of CAD, to promote angiogenesis,
and/or as AGE Crosslink Breakers, among other drugs. For instance, the
systems and methods reduce or eliminate the incidence of CAD and related
morbidities, improve symptoms resulting from CAD, and/or improve cardiac
blood flow, cardiac function, and patient quality of life.