A circuit and method of qualified anomaly detection provides detection and triggering on specific analog anomalies and/or digital data within a qualified area of a serial data stream. A start pattern within the serial data stream, such as a packet header, is detected to generate an enable signal. A stop event, such as a packet trailer, a specified digital event, a time interval or the like, is identified to generate a disable signal. The enable and disable signals are combined to produce a qualification signal that allows a trigger circuit to trigger on a specified anomaly within the portion of the serial data stream defined by the qualification signal.