A device for device for applying a plurality of microdroplets onto a substrate has a plurality of nozzle orifices in a dosing head. In addition to walls for defining a liquid column of a medium to be dosed on each nozzle orifice, a pressure chamber is provided, which is adapted to be filled with a buffer medium and which is arranged in such a way that said buffer medium can simultaneously be used for applying a pressure to the liquid-column ends which are spaced apart from the nozzle orifices. A pressure generator is provided for applying a pressure to said buffer medium in such a way that a plurality of microdroplets will simultaneously be applied onto the substrate through said plurality of nozzle orifices. Finally, liquid reservoirs for the media to be dosed, which are in fluid communication with the liquid columns on the nozzle orifices are provided.