A stimulus compression device determines neuro-feedback significance corresponding to stimulus material and modifies the stimulus material using neuro-feedback significance measures. For example, the stimulus compression device determines portions of a media stream corresponding to low neuro-feedback significance and removes them from the media stream. Compression of stimulus material may involve removal, modification, repetition, bit rate adjustment, resolution adjustment, etc. Transitions can be smoothed or lengthened to further improve processed stimulus material.

 
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