A process for integrity check of lots of individual package units which comprises combining at least one RFID tag and a container which contains a large number of individual package units wherein each of the individual package units is marked with a marking code, the information of these codes of all individual package units is combined, and a hash code is generated based on the combined information of all marking codes of all individual package units, which combined hash code is stored in an RFID tag which is affixed to the container, this combined hash code together with the individual hash codes for the individual package units being stored in the data base of the SENDER site where the container is packed and sealed, the individual hash codes then being transmitted to the RECIPIENT of the said container, the information collected from the RFID tag being compared to the combined hash code which is calculated at the RECIPIENT site from the information received by the SENDER of the said container including all individual hash codes of all package units in the said container, and to the combined hash code calculated from the markings on the individual package units or boxes scanned at the RECIPIENT site, and the application of the said process in the verification of the integrity of pharmaceutical goods, video information such as movies on DVD, audio information such as music on CD, computer files, or paper documents.