Embodiments of the present invention provide a method, apparatus and system of interference mitigation in wireless communication. In some demonstrative embodiments the method may include determining one or more factors to be applied to one or more likelihood ratio values of one or more current symbols received by a station over one or more communication subcarriers, respectively, based on one or more sets of estimated error values, respectively, wherein the set of error values corresponds to a plurality of previous symbols received over the subcarrier. In some demonstrative embodiments the method may include determining the likelihood ratio value based on a probability that the current symbol includes interference caused by one or more other stations transmitting over the subcarrier. Other embodiments are described and claimed.