2-Chloro-9-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-9H-purin-6-amine
is synthesized by reacting a 2-chloro-6-substituted purine with a
protected and activated 2-deoxy-2-fluoro-D-arabinofiranose; and reacting
with a base such as ammonia to provide
2-chloro-9-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-9H-purin-6-amine.
When the purine reactant is substituted in the 6 position with a halogen,
a reaction step with an alkoxide is carried out prior to the reaction
with ammonia.