A power supply switch circuit with current leakage protection is used in an electronic device, and is able to prevent the erroneous actions caused by a leakage current in high-temperature environments. The power supply switch circuit comprises a transistor having an emitter, a base and a collector, a field effect transistor having a drain, a source and a gate, and at least two series-connected diodes. The emitter is connected to a voltage source. The collector is connected to a load via a forward biased diode. The drain receives a trigger signal. The source is connected a reference terminal via at least two series-connected diodes. The gate is connected to the collector via a second resistor. One terminal of a third resistor is connected to the gate, and the other terminal is connected to the reference terminal.