A process is described for the degradation, detoxification and decontamination treatment of contaminated solid or liquid matrices and/or relative functional revalorisation and for their sterilisation, which comprises placing said matrix in contact with at least one saline catalyst and at least one oxidising agent chosen from among percarbonates, perborates or metal peroxides in the presence of a last one energy source chosen from among microwaves (MW), ultrasounds (US) and ultraviolet rays (UV).