Systems and method are disclosed for internal matching and configuration of radio frequency communication modules and antenna systems within a portable information handling system to help alleviate contentions among wireless communication technologies. A database stores operational information associated with wireless communication radio modules and antenna systems. A central control and switching module then matches and configures antenna systems and communication modules based upon stored operational information. The stored information can include device requirements, regional communication requirements, communication protocols and/or any other desired operational information. Flexibility is thereby provided for wireless communications, and worldwide intelligent access is allowed to radio frequency (RF) spectrums while adhering to localized spectrum and regulatory policies.