The subject matter hereof relates to systems and methods of providing for correction of image signals characteristic of non-uniform images. Various example embodiments of systems and methods so providing correction include embodiments directed to endoscopic imaging systems, endoscopes, and endoscopic imaging methods. Various example embodiments of systems and methods so providing correction include embodiments: that establish one or more correction factors and correct selected image data using at least one of such correction factors; and/or that establish one or more correction factors in performing a trigger operation, e.g., a white balance operation.