A fuel cell layer and methods for making a fuel cell layer comprising at least one fuel cell in communication with first reactant plenum and second reactant plenum, wherein one of the reactant plenums contains oxidant and the other reactant plenum contains fuel. The fuel cell comprises a gas barrier region formed by disposing gas barrier material on a substrate; a second region having a first port formed on the gas barrier; a first gas diffusion electrode having a first seal disposed around the electrode; an electrolyte region formed by disposing electrolyte material on the second region; a fourth region having a second port formed on the electrolyte region; a second gas diffusion electrode having a second seal disposed around the electrode, wherein the second and fourth regions are in communication with the electrolyte region, and the gas barrier region separates the first reactant plenum from the second reactant plenum.