The present invention relates to methods of treating ischemia-related
conditions by administering to a patient in need of such methods certain
thiosemicarbazone compounds. Preferred embodiments of the present
invention relates to methods of treating specific ischemia-related
conditions, including but not limited to Alzheimer's disease, Parkinson's
disease, Coronary artery bypass graft surgery, Global cerebral ischemia
due to cardiac arrest, focal cerebral infarction, cerebral hemorrhage,
hemorrhage infarction, hypertensive hemorrhage. hemorrhage due to rupture
of intracranial vascular abnormalities, subarachnoid hemorrhage due to
rupture of intracranial arterial aneurysms, hypertensive encephalopathy,
carotid stenosis or occlusion leading to cerebral ischemia, cardiogenic
thromboembolism, spinal stroke and spinal cord injury, diseases of
cerebral blood vessels: e.g., atherosclerosis, vasculitis, Macular
degeneration, myocardial infarction, cardiac ischemia and
superaventicular tachyarrhytmia.