A method for radiation therapy with target recognition has a first target identification system for obtaining first target characteristics within a patient's body. A second target identification system obtains second target characteristics within the body aided by the first target characteristics. A computation means for calculation of three-dimensional coordinates of the target region with respect to a three-dimensional radiotherapy system uses the second target characteristics. Irradiation means for radiotherapy mode adaptation is used in response to the second target characteristics and the calculation of three-dimensional coordinates of the target region.