A method for express activation of multimedia playing for a computer multimedia system with a hot key standby state is provided. The computer of the computer multimedia system, after completing BIOS booting and operating system booting, enters a hot key standby state. In the hot key standby state, when a preset hot key is operated, the computer awakes from the hot key standby state and enters a multimedia operational state. The computer loads and executes the multimedia device driver to activate the multimedia device. Then, the computer loads and executes the multimedia device application program to operate the multimedia device.