The present invention relates to composite materials for bone replacement comprising organic and inorganic material, more particularly to composite materials for bone replacement wherein cyanoacrylate as organic material and osteo-conductive inorganic material as inorganic material are combined. The composite materials synthesized according to the present invention, maximize the merits of organic material and inorganic material and minimize their demerits. In detail, the organic material has the maintenance of shape and the adhesive property and the inorganic material has the osteo-conductivity on a new bone. Therefore, the composite materials of the present invention can be applied to fill bone defects and replace bones, since they retain the excellent physical property.